#collagen

GHK-Cu Copper Peptide Mechanism — Research Review

GHK-Cu is the copper-bound form of the tripeptide Gly-His-Lys, originally isolated from human plasma in the 1970s. It's one of the few peptides whose mechanism is dominated by extracellular-matrix remodelling rather than receptor-driven signalling. This post walks through what's actually happening at the molecular level — collagen synthesis upregulation, matrix metalloproteinase modulation, dermal papilla cell stimulation, and the antioxidant axis.